Soluble Sulphonamide Compounds

Synthesis, Characterization, and Antitumor Activity of Four Novel Sulphonamide compounds

Abstract: A selected series of substituted sulphonamides were synthesized. These compounds were tested for potential antitumor activity against three of human tumor cell lines, Liver carcinoma cell line [HEPG2], Brain tumor cell line [U251] and Colon carcinoma cell line [HCT116]. Cytotoxic activity was assessed by SRB assay. The structures of the resulting compounds have been investigated by el...

Biliary Excretion of Foreign Compounds SULPHONAMIDE DRUGS IN THE RAT

1. The extent of biliary excretion in the rat of 15 sulphonamide compounds was studied. 2. Most of the sulphonamides studied, with molecular weights from 172 (sulphanilamide) to 352 (N4-acetylsulphadimethoxine) are poorly excreted in the bile (0-4% of the dose), except sulphapyridine, sulphamethoxypyridazine and sulphadimethoxine. The last three are partly metabolized to glucuronides, whose mol...

Sulphonamide Anuria

A Mohammedan male, aged 15 years, was admitted to the surgical ward of this hospital on 29th December, 1945, for osteomyelitis of the right leg. A course of sulphonamide two tablets thrice daily was prescribed and the leg was operated on. Ten days later he showed signs of pain and fullness over the back and loin, and there was complete anuria. Sulphonamide was at once stopped, and alkaline mixt...

Respiratory carcinogenicity assessment of soluble nickel compounds.

The many chemical forms of nickel differ in physicochemical properties and biological effects. Health assessments for each main category of nickel species are needed. The carcinogenicity assessment of water-soluble nickel compounds has proven particularly difficult. Epidemiologic evidence indicates an association between inhalation exposures to nickel refinery dust containing soluble nickel com...

Smallpox and Sulphonamide